关于表观遗传的随机性,和癌症风险
1CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institute for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People's Republic of China.
概括
衰老和癌症风险因素导致准静态表观遗传变化,主要是DNA甲基化 (DNAm) 变化. 这些与细胞增殖相关的变化,为使用表观遗传钟预测癌症风险提供了新的策略.
科学领域:
- 表观遗传学和癌症生物学
- 疾病发展中的随机过程.
背景情况:
- 表观遗传变化,包括DNA甲基化 (DNAm),随着年龄和暴露于癌症风险因素而累积.
- 这些与年龄相关的表观遗传变化以准静态的方式发生,并且越来越多地与癌症的发展有关.
研究的目的:
- 描述DNA甲基化在衰老和癌前细胞中的变化的准随机性质.
- 讨论对癌症风险预测策略和癌症风险标志物的选择的影响.
- 探索与年龄相关的DNA甲基化变化在癌症发展中的因果作用.
主要方法:
- 对与年龄相关的DNA甲基化模式的证据的审查和综合.
- 讨论DNA甲基化,细胞增殖和组织周转之间的关系.
- 分析表观遗传变化与促进癌症干细胞状态之间的联系.
主要成果:
- 衰老和癌症风险因素诱导 DNA 甲基化变化的准静态变化.
- 很大一部分DNA甲基化变化与细胞增殖有关,使得癌症风险预测的表观遗传线粒状时钟的发展成为可能.
- 与年龄相关的DNA甲基化变化可能通过抑制转录因子,增加表观遗传和转录基因,并促进癌症干细胞状态,因果地导致癌症.
结论:
- 表观遗传变化的随机性质需要在癌症风险标志物选择中进行范式转变.
- 基因表观线粒状钟表代表了预测癌症风险的有希望的途径.
- 与年龄相关的表观遗传变化在癌症发病和进展中发挥着潜在的因果作用.
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