心房动症状与临床结果之间的关联:一个前性的多中心注册研究
Sang Jun Lee1, Junbeom Park2, Jin-Kyu Park3
1Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
The American journal of cardiology
|March 3, 2024
概括
症状和无症状心房动 (AF) 患者具有相似的心血管风险,尽管无症状个体显示左心房大小增加. 对AF的治疗决定不应该仅仅取决于症状的存在.
科学领域:
- 心脏病学 心脏病学
- 耳前的研究研究研究.
- 临床结果 临床结果
背景情况:
- 症状的存在会影响心房动 (AF) 的治疗策略 (节律与节率控制).
- 之前关于症状与无症状AF临床结果的研究表明结果不一致.
- AF症状与左心房 (LA) 改造之间的关系尚未得到充分证实.
研究的目的:
- 为了比较症状和无症状的非膜性心房动 (AF) 患者的临床结果.
- 为了研究AF症状与左心房 (LA) 改造之间的关联.
主要方法:
- 从前性多中心对比研究中对患者的分析 药物用于控制症状和预防AF并发症 (CODE-AF) 注册表.
- 10,210名AF患者的分层分为症状 (42%) 和无症状组.
- 主要结局:综合所有死因,缺血性中风,过时缺血性发作,全身血栓塞,心肌梗塞和心力衰竭住院治疗.
主要成果:
- 无症状组表现出更大的平均左心房 (LA) 直径 (43.6毫米对42.2毫米,p <0.001).
- 在32.9个月的中位随访期间,无症状和有症状组之间的初级结局发生率相似 (1.44对1.45每100人年;日志排名,p = 0.8).
- 无症状的AF患者年龄较大,男性的比例较高,高血压和糖尿病较高.
结论:
- 缺少AF症状与左心房大小增加有关.
- 症状和无症状的AF患者对主要心血管结局的风险相似.
- 在症状和无症状患者群体中,AF治疗的疗效可能是一致的.
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