在有或没有尿失禁的女性中,对认知能力下降的长度研究
Rachel A High1, Miriam Alvarez2, Brachel Champion3
1Department of Women's Health, Dell Medical School, University of Texas at Austin, Austin, TX; Houston Methodist Hospital, Houston, TX.
American journal of obstetrics and gynecology
|March 3, 2024
概括
70岁前女性的尿失禁在十年内没有显著影响认知能力下降或痴呆风险. 认知表现在不和大陆群体中同样下降.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 以前的研究表明,尿失禁 (UI) 和认知能力下降之间存在联系.
- 需要进行纵向研究来确定时间关联.
- 健康与退休研究 (HRS) 提供了关于老年人的认知功能和UI的纵向数据.
研究的目的:
- 研究70岁前尿失禁对女性认知功能变化的影响.
- 为了确定UI是否是认知能力下降或痴呆症概率增加的风险因素.
主要方法:
- 来自58-67岁妇女的HRS数据的二次分析,至少有两次认知评估.
- UI定义为前12个月内任何非自愿的尿失.
- 粗精确匹配用于创建可比的对照组.
- 记忆得分和痴呆症概率每两年评估一次,使用经过验证的神经心理测试.
- 线性回归模型根据基线人口统计和并发病情况进行调整.
主要成果:
- 40.6%的女性在58-69岁之间报告UI.
- 在UI和对照组中,记忆得分显著下降,两者之间没有显著差异.
- 在这两组中,痴呆症的概率都增加了,但没有发现显著差异.
- 频繁的UI没有显示与认知变化的剂量反应关系.
结论:
- 在大约10年的观察中,认知表现下降了.
- 在70岁之前尿失禁的存在与这个队列的认知能力下降率或痴呆症概率增加无关.
- 进一步的研究可能会探索其他导致老年妇女认知能力下降的因素.
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