长期禁食诱导了日本的雌性的基本热生成灵活性
Jie-Heng Xu1, Xin-Yu Xu1, Xing-Yu Huang1
1School of Life and Environmental Sciences, Wenzhou University Chashan University Town, Wenzhou 325035, China; Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou, China.
概括
在长时间的禁食期间,雌性日本鱼表现出三相代谢变化,反映了雄性. 这种适应性反应涉及基本代谢率和体温的显著降低,有助于生存.
科学领域:
- 比较生理学比较生理学
- 鸟类的新陈代谢.
- 热调节 热调节 热调节
背景情况:
- 雄性日本黄表现出长期禁食的三阶段代谢适应,包括减少基底热生成.
- 之前的研究指出,日本的体温有基于性别的差异.
- 雌性日本白对禁食的代谢和发热反应在很大程度上仍然没有特征.
研究的目的:
- 为了调查日本的雌性是否在长时间的饥饿中表现出类似的三相代谢变化,就像在雄性中观察到的那样.
- 阐明与雌性的这些代谢转变相关的潜在热生成机制.
- 在多个生物层面评估适应性反应,从生物到分子.
主要方法:
- 雌性日本被 subjected to 长时间的饥饿. 在日本,女性被 subjected 长期的饥饿.
- 测量包括身体质量,基础代谢率 (BMR),体温,组织/器官质量,体脂和状态-4呼吸 (S4R) 以及肌肉和肝脏中的细胞染色体c氧化酶 (CCO) 活性.
- 血清分析葡萄糖,甘油三 (TG),尿酸和甲状腺激素 (T3,T4);肌肉mRNA水平的肌素 (MSTN) 和鸟类解蛋白 (av-UCP) 也被评估.
主要成果:
- 在禁食的雌性日本中观察到与雄性相似的三相代谢反应.
- 禁食导致身体质量,BMR,体温,组织/器官质量以及肌肉和肝脏中的S4R/CCO活性下降.
- av-UCP mRNA水平下降,MSTN mRNA在I/II期增加,然后在III期下降,血清T3水平和T3/T4比率下降.
结论:
- 雌性日本白表现出适应长期禁食的策略,包括协调,多层次调整基底热生成.
- 这些综合的调整,跨越生物体,生化,酶,细胞,遗传和内分泌水平,对于在长时间的饥饿期间的生存至关重要.
- 这些发现突出了日本的保存适应机制,在温度调节和代谢控制方面特别考虑了基于性别的因素.
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