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淋巴细胞计数在自身免疫性糖尿病病中的临床价值

Zhongyuan Xiang¹, Wen'en Liu², Sangya Fu³

¹Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha 410008. xiangzhongyuan@csu.edu.cn.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

|March 3, 2024

概括

淋巴细胞计数与自身免疫性糖尿病中的糖尿病病 (DN) 密切相关. 这表明淋巴细胞可能是早期DN风险识别和潜在治疗点的生物标志物.

科学领域:

内分泌学和新陈代谢学
免疫学免疫学免疫学
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

糖尿病病 (DN) 的患病率正在上升,越来越多的证据表明淋巴细胞相关的炎症反应.
自身免疫性糖尿病,包括1型糖尿病 (T1D) 和成年人潜在自身免疫性糖尿病 (LADA),在管理DN方面提出了独特的挑战.
了解淋巴细胞在DN病原发生中的作用对于开发向疗法至关重要.

研究的目的:

研究自身免疫性糖尿病 (T1D和LADA) 患者的淋巴细胞计数和DN之间的关系.
识别淋巴细胞作为早期DN检测和治疗点的潜在生物标志物.

主要方法:

对226名T1D和79名LADA患者的回顾性研究,按尿中的白蛋白与肌素比率 (ACR) 分层.
分析临床数据,包括血压,尿酸和糖尿病持续时间.
相关性分析和后勤回归以确定DN的风险因素,重点是淋巴细胞.

主要成果:

与LADA患者相比,T1D患者的淋巴细胞数量较高,中性粒细胞与淋巴细胞比率 (NLR) 较低.
在T1D患者中,淋巴细胞计数低于 normoalbuminuria,而不是 macroalbuminuria.
逻辑回归确认的淋巴细胞在T1D中与DN独立相关,这表明在病变发生过程中发挥了作用.

结论:

淋巴细胞计数与自身免疫糖尿病患者的DN密切相关.
淋巴细胞介导的炎症可能在DN发育中发挥重要作用.
淋巴细胞显示出作为DN风险的早期生物标志物和治疗点的潜力.

关键词:

自身免疫性糖尿病是一种糖尿病.生物标志物生物标志物糖尿病性脏病糖尿病脏病淋巴细胞的淋巴细胞.

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