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Updated: Jul 1, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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关于NR4A核受体家族及其潜在内源性配体的结构视角

Ryoichi Hashida1,2, Takeshi Kawabata3

  • 1Genox Research Inc.

Biological & pharmaceutical bulletin
|March 3, 2024
PubMed
概括

前列腺素PGA1和PGA2激活NR4A核受体家族. 这些发现提供了对帕金森氏症等神经系统疾病的潜在治疗方法的见解.

关键词:
复杂结构的同质模型 (HOMCOS)这是内源性联结体.连带结合域是一个连带结合域.核受体子家族4A组 (NR4A) 的核受体一个前列腺腺腺素A.基于模板的建模.

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