一个COVID-19的尸检病例与新的扩散性肺部骨化
Taisuke Nakagawa1,2, Yasuaki Kotetsu1, Katsumi Takizawa3
1Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Japan.
Internal medicine (Tokyo, Japan)
|March 3, 2024
概括
一名61岁的免疫抑制患者患有复发性多合体炎,尽管接受了密集治疗,但因2019年新冠肺炎 (COVID-19) 死亡. 尸体解剖揭示了扩散的膜损伤,肺部骨化和细胞大脑病毒感染,突出显示了严重的COVID-19并发症.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 2019年新冠肺炎疾病 (COVID-19) 对免疫力低下的个体构成重大风险.
- 复发性多合体炎是一种影响软骨的全身炎症状况.
研究的目的:
- 描述一个致命的COVID-19病例的临床过程和病理发现,在一个免疫抑制患者的复发性多重合体炎.
- 讨论严重的COVID-19在患有自身免疫性疾病的患者的影响.
主要方法:
- 一个61岁的男性患者的病例报告.
- 对临床数据,治疗干预措施和尸检结果的审查.
- 肺组织的组织病理学检查.
主要成果:
- 患者患有严重的COVID-19,需要输管和机械通风.
- 治疗包括类固醇,雷梅西维尔,抗生素,巴里西提尼布和托西利祖马布.
- 尸体解剖显示了扩散的膜损伤,肺部骨化和细胞大脑病毒感染.
结论:
- 严重的COVID-19可以导致免疫抑制患者的致命后果,即使使用多模式治疗.
- 肺部并发症,如扩散膜损伤和骨化可能会发生.
- 细胞巨乳病毒的同时感染可能会导致免疫功能低下的主体的疾病严重程度.
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