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冠状动脉微血管功能障碍:怀疑心肌缺血症患者的患病率和病因学

H Kong¹, J Cao¹, J Tian²

¹Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

Clinical radiology

|March 3, 2024

概括

冠状动脉微血管功能障碍 (CMD) 影响79%的怀疑心肌缺血的患者,经常与非阻塞性冠状动脉疾病和多变性心肌病相关.

科学领域:

心脏病学心脏病学
心血管成像 - 心血管成像
肌心输血是指肌心输血.

背景情况:

冠状动脉微血管功能障碍 (CMD) 在表现为心肌缺血症状的患者中越来越多地被认可.
了解CMD的患病率和病因因素对于准确的诊断和管理至关重要.

研究的目的:

在怀疑心肌缺血症的患者中确定冠状动脉微血管功能障碍 (CMD) 的患病率和原因.
调查CMD与各种病因因素之间的关联,包括冠状动脉疾病 (CAD) 和多变性心肌病 (HCM).

主要方法:

103名怀疑心肌缺血的患者接受了压力输液心脏磁共振成像 (CMR).
冠状动脉微血管功能障碍 (CMD) 被视觉评估并使用心肌输液储备指数 (MPRI) 量化.
使用CVI42软件分析左心室 (LV) 应变参数.

主要成果:

冠状动脉微血管功能障碍 (CMD) 在79%的研究队列中存在.
非阻塞性冠状动脉疾病 (CAD) 是最常见的病因 (88%),其次是阻塞性CAD (8%) 和多变性心肌病 (HCM) (4%).
患有CMD的发病率在患有HCM (100%) 和非阻塞性CAD (79%) 的患者中最高.

结论:

冠状动脉微血管功能障碍 (CMD) 在怀疑心肌缺血症的患者中非常普遍.
冠状动脉疾病与非阻塞性冠状动脉疾病,阻塞性冠状动脉疾病和HCM相关,HCM的患病率特别高.
需要进一步研究CMD在这些患者群体中的特定机制和临床影响.

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