血代谢物和七种癌症的风险:在欧洲后裔中进行两样本的孟德尔随机化研究
Yaxin Chen1,2, Yufang Xie2, Hang Ci1
1Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Guoxue Alley 37, Chengdu, Sichuan, China.
BMC medicine
|March 3, 2024
概括
这项研究使用了门德尔的随机化来研究66种血代谢物与癌症风险之间的因果关系. 结果揭示了与肺癌和细胞癌相关的特定代谢物,有助于未来的风险评估.
科学领域:
- 代谢学 代谢学 代谢学
- 遗传学 是一个遗传学.
- 癌症研究 癌症研究
背景情况:
- 循环中的代谢物越来越多地与癌症风险有关,但因果关系尚不清楚.
- 研究这些联系对于理解癌症病因和制定预防策略至关重要.
研究的目的:
- 评估913种血代谢物与7种癌症的风险之间的潜在因果关系,使用全面的双样本孟德尔随机化 (MR) 研究.
- 为了确定可能因果关系影响癌症风险的特定代谢物.
主要方法:
- 使用全基因组关联研究 (GWAS) 数据对913种血代谢物和7种癌症类型进行了一项双样本的门德尔随机化 (MR) 研究.
- 逆方差加权 (IVW) 方法是主要分析方法,通过加权中位数MR,埃格尔回归,MR-PRESSO和反向MR分析进行额外的审查.
- 使用独立数据集进行复制分析.
主要成果:
- 确定了94个显著的关联,表明66种不同的血代谢物与7种癌症的风险之间存在因果关系.
- 甲基甲醇硫酸盐和4-乙烯硫酸盐与肺癌和脏细胞癌症风险的关联最明显,分别是.
- 没有任何显著的关联被弱小的仪器,变性或反向因果关系所偏见,复制分析支持了主要发现.
结论:
- 在66种血代谢物和癌症风险之间建立了合理的因果关系,提高了对它们在癌症遗传学和病因学中的作用的理解.
- 这些发现为改善癌症风险评估和预防策略提供了潜力.
- 进一步研究这些代谢物与癌症的联系是有必要的.
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