生物学和向治疗中的NF-κB:新的见解和转化影响
Qing Guo1,2, Yizi Jin1,2, Xinyu Chen3
1Department of Medical Oncology, Fudan University Shanghai Cancer Center, No. 270, Dong'an Road, Shanghai, 200032, China.
Signal transduction and targeted therapy
|March 3, 2024
概括
核因子kappa B (NF-κB) 信号传递在炎症和疾病中至关重要. 本综述详细介绍了其机制,相互作用,疾病参与以及未来研究和临床实践的治疗策略.
科学领域:
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 核因子kappa B (NF-κB) 信号传导已知近40年,最初被认为是其在炎症中的作用.
- 广泛的研究揭示了它在各种信号通路,生物过程和人类疾病中的更广泛参与.
研究的目的:
- 提供NF-κB信号的全面审查,包括其组成,激活和调节.
- 探索NF-κB与其他关键信号通路的相互作用.
- 阐明NF-κB在各种生理和病理状态,包括疾病和治疗中的作用.
主要方法:
- 文献综述和对NF-κB信号传导现有研究的综合.
- 对NF-κB与PI3K/AKT,MAPK,JAK-STAT等途径的相互作用进行分析.
- 检查NF-κB在炎症,免疫力,瘤微环境和各种人类疾病中的参与.
主要成果:
- NF-κB信号传递与炎症,免疫调节和瘤微环境密切相关.
- NF-κB的失调与癌症,炎症性疾病,心血管疾病,代谢障碍,神经疾病和COVID-19有关.
- 目前正在研究针对NF-κB信号的各种治疗策略,包括抑制剂和免疫疗法.
结论:
- NF-κB信号传递是一个多方面的途径,在许多生物过程和疾病中具有深远的影响.
- 了解NF-κB的复杂作用为开发新型治疗干预提供了巨大的潜力.
- 本综述提供了一个全面的概述,以指导NF-κB向治疗的未来研究和临床应用.
更多相关视频
09:52A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
Published on: December 4, 2018
7.5K
10:57NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
Published on: January 12, 2020
10.6K
相关概念视频
NF-κB-dependent Signaling Pathway
7.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.4K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Cytotoxic T Cells-mediated Immune Response
908
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
908
Co-activators and Co-repressors
7.4K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
7.4K
M-Cdk Drives Transition Into Mitosis
5.6K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.6K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
