Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The genomic and spatial transcriptomic landscape of seborrheic keratoses.

The Journal of investigative dermatology·2026
Same author

The burning question: Does exposure to low dose and low irradiance ultraviolet radiation lead to cutaneous DNA damage in people with skin types I-III?

Photochemistry and photobiology·2026
Same author

Rapid-access oncodermatology is associated with reduced corticosteroid use and supports continuation of anticancer therapy after treatment-related cutaneous toxicity.

JAAD international·2026
Same author

Dermatologists' Perspectives on Referral Systems and Legal Risk: Insights From a National Survey.

The Australasian journal of dermatology·2026
Same author

Skin cancer mortality in Australian and New Zealand kidney transplant recipients: A population-based cohort study using linked health data, 1990-2019.

The British journal of dermatology·2026
Same author

Synonymous substitutions confer the conserved <i>WPRa4</i> as a novel target of miR396 in cucumber.

Horticulture research·2026

相关实验视频

Updated: Jun 18, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

14.6K

扩散标志物Ki67的淋巴体表达与初级皮肤黑色素瘤中的哨戒节阳性,复发和死亡率有关.

Samuel X Tan1, Sharene Chong1, Casey Rowe1

  • 1Frazer Institute, University of Queensland, Brisbane, Queensland, Australia.

Experimental dermatology
|March 4, 2024
PubMed
概括

新出现的淋巴血管生成,以D2-40+/Ki67+联合表达为标志,信号增加了黑色素瘤风险. 这一发现突显了淋巴增殖作为一种关键指标,用于黑色素瘤特异性死亡率和复发在原发性皮肤黑色素瘤患者.

关键词:
生物标志物生物标志物免疫光效应 免疫光效应黑色素瘤是一种黑色素瘤.病理学的病理学预后 预后 预后

更多相关视频

Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

7.0K
Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
08:18

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma

Published on: September 8, 2021

2.9K

相关实验视频

Last Updated: Jun 18, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

14.6K
Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

7.0K
Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
08:18

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma

Published on: September 8, 2021

2.9K

科学领域:

  • 在瘤学瘤学.
  • 皮肤病学 皮肤病学
  • 病理学 病理学 病理学

背景情况:

  • 淋巴细胞生成,新淋巴血管的形成,在淋巴血管入侵之前.
  • 淋巴血管侵袭与原发性皮肤黑色素瘤中更高的转移和死亡风险有关.
  • 识别黑色素瘤进展的早期指标对于患者的预后至关重要.

研究的目的:

  • 调查新兴淋巴细胞生成与原发性皮肤黑色素瘤的预后之间的关联.
  • 评估内皮蛋白与Ki67的共同表达是否预测了较差的结果.
  • 为了确定黑色素瘤患者淋巴扩散的预后值.

主要方法:

  • 对264名原发性皮肤黑色素瘤患者进行了回顾性纵向研究.
  • 对内皮蛋白 (CD31,D2-40) 和Ki67.7.0进行欧帕尔多重体免疫光染色.
  • 多变量考克斯回归分析,以评估内皮基67阳性和临床结果之间的关联.

主要成果:

  • 同时表达D2-40+/Ki67+与瘤特异性死亡率 (aHR:2.03) 和复发率 (aHR:1.70) 的增加显著相关.
  • 在这个队列中,CD31+/Ki67+联合表达没有显示出预后意义.
  • 通过D2-40+/Ki67+共同表达识别的淋巴增殖预测了较差的结果.

结论:

  • 新兴淋巴血管生成,特别是D2-40+/Ki67+联合表达,是原发性皮肤黑色素瘤不良结果的重要预测因素.
  • 这种淋巴扩散的标志物可能表明转移和死亡的风险更高.
  • D2-40+/Ki67+联合表达可以帮助黑色素瘤患者的风险分层.