老年人与 transthyretin 心脏 Amyloidosis 的步行异常
Fitsum E Petros1, Alfonsina Mirabal Santos2, Adedeji Adeniyi3
1Department of Mechanical Engineering, Columbia University, New York, NY, USA.
概括
老年人患有跨氨基粉症 (ATTR心脏粉症) 呈现出改变的步态,包括更慢,更窄的步伐. 步态分析可能有助于表征疾病,并为患者的护理提供信息.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年病的医生 老年病的医生
背景情况:
- 晶氨酸心肌粉症 (ATTR心肌粉症) 是由变异性 (ATTRv) 或野生型 (ATTRwt) 晶氨酸引起的.
- 在年轻的ATTRv氨基粉症患者中记录了走路异常,但在老年ATTR心脏氨基粉症患者中进行的研究有限.
- ATTR心脏粉症与神经病变和骨科问题有关,需要对这一人口群体的步态特征进行调查.
研究的目的:
- 为了研究老年男性患者的步态模式,诊断出ATTR心脏粉症.
- 为了比较ATTR心脏粉症患者和健康的老年男性对照之间的步态参数.
- 探索步行特征与疾病严重程度的临床/功能评估之间的关系.
主要方法:
- 二十八名老年男性ATTR心脏粉症患者和11名健康的老年男性对照参与了这项研究.
- 在地面行走时使用仪器床评估步态,有和没有双重认知任务.
- 测量的关键步行参数包括步幅,长度,速度和立场时间百分比.
主要成果:
- 与对照组相比,ATTR心脏粉症患者表现出明显不同的步态,其特点是变化性增加,速度减慢,步伐更窄和更短.
- 与摇摆相比,患者表现出长时间的姿势阶段 (脚在地面上).
- 观察到的步态差异与ATTR心脏粉症严重程度的临床或功能测量之间没有显著的相关性.
结论:
- 步态分析提供了一种潜在的补充方法来表征ATTR心脏粉症.
- 研究结果可以为与跌倒风险,抗凝血和维持功能独立性相关的临床管理策略提供信息.
- 进一步的研究可以将步态分析纳入ATTR心脏粉症的例行患者评估中.
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