乳头共变网络与脑小血管疾病患者的认知缺陷有关
Wei Yan1, Siwei Tang1, Li Chen1
1Department of Radiology, Affilated Hospital of North Sichuan Medical College, NanChong, 637000, Sichuan, China.
Annals of clinical and translational neurology
|March 4, 2024
概括
大脑小血管疾病 (CSVD) 患者表现出与认知障碍相关的乳头共变网络减少. 这种网络可以作为早期的神经成像生物标志物,用于识别CSVD的认知缺陷.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 大脑结构分析 分析大脑结构
背景情况:
- 大脑小血管疾病 (CSVD) 与广泛的灰质异常有关.
- 在CSVD中灰质缩区域的皮层-皮层连接的性质仍然不清楚.
- 研究灰色物质共变网络可以阐明这些联系及其与认知功能的关系.
研究的目的:
- 为了比较有或没有认知障碍 (CI) 的CSVD患者的灰质共变网络.
- 确定与CSVD认知缺陷相关的特定结构共变网络.
- 评估这些网络作为CSVD早期CI检测生物标志物的潜力.
主要方法:
- 基于来源的形态分析 (SBM) 用于建模61名CI的CSVD患者,85名没有CI的CSVD患者和108名健康对照者的灰质体积.
- 结构共变网络被生成并分析了CSVD患者与认知功能的相关性.
- 一个支持向量机 (SVM) 分类器利用灰色物质共变网络在CSVD群体中识别CI.
主要成果:
- 与对照组相比,CSVD患者在乳头皮层,大脑皮层和皮层共变网络中的表达减少.
- 患有CI的CSVD患者显著减少了thalamic共变性网络表达,涉及thalamus和parahippocampal gyrus.
- 即使在排除患有乳头缺陷的患者后,也观察到这种乳头网络的减少,并且与认知功能有积极的相关性.
结论:
- 胸膜共变网络是CSVD早期灰色物质减少的核心区域,与认知缺陷直接相关.
- thalamic共变网络的减少表达提供了证据,证明它在CSVD认知障碍的发展中的作用.
- 这种网络可以作为一种潜在的神经成像生物标志物,用于早期识别CSVD患者的认知障碍.
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