压力特异性干预对癌症患者生物标志物水平和认知功能的影响:系统性审查和元分析
Xiaotong Ding1, Mingyue Zhu1, Fang Zhao2
1School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
British journal of health psychology
|March 4, 2024
概括
压力特定干预措施有利于癌症患者.
科学领域:
- 在瘤学瘤学.
- 心理神经免疫学 心理神经免疫学
- 基于证据的医学 基于证据的医学
背景情况:
- 长期的压力会对癌症患者的心理和生理健康产生负面影响.
- 关于应激干预措施的先前研究表明结果不一致,统计能力有限.
- 需要进行元分析,以澄清压力干预在癌症护理中的影响.
研究的目的:
- 系统地评估癌症患者应激特异性干预措施的有效性.
- 综合来自随机对照试验 (RCT) 关于瘤学压力干预的研究结果.
- 评估对认知功能和生物标志物水平的影响.
主要方法:
- 在九个数据库中进行了全面的文献搜索,直到2024年1月.
- 在元分析中包括了19个随机对照试验 (RCT).
- 使用Cochrane偏差风险工具 (RoB2) 评估了偏差风险;使用Review Manager 5.4.4进行的元分析.
主要成果:
- 特定于压力的干预措施对癌症患者的主观认知功能产生了积极的影响.
- 对执行功能和特定生物标志物的影响 (例如TNF-α,皮质醇,IL-10,IL-8,IL-6,IL-1,CRP) 是不确定的或不存在的.
- 九个RCT被评为偏差风险低,其他则具有中等风险.
结论:
- 需要进一步进行高质量的研究,以确认压力干预对生物标志物水平的影响.
- 这些干预措施影响癌症患者认知功能的精确机制需要进一步研究.
- 目前的证据表明对主观认知有好处,但生物标志物效应仍然没有确定性.
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