相关实验视频

Updated: Jul 1, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

[胃肠癌中的循环RNA编码蛋白:一篇评论]

Jie Jiang¹, Zai Luo¹, Hao-Liang Zhang¹

¹Department of Gastrointestinal Surgery,Shanghai General Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200080,China.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

|March 4, 2024

概括

循环RNAs (CircRNAs) 是一种独特的RNA类型,可以产生影响癌症等疾病的蛋白质. 了解这些CircRNA编码的蛋白质为瘤提供了新的诊断和治疗策略.

科学领域:

分子生物学分子生物学
遗传学遗传学是一个
生物化学生化学

背景情况:

循环RNA (CircRNAs) 是具有稳定,闭环结构的非编码RNA,与线性RNA不同.
新兴研究显示,某些CircRNAs可以使用独立于cap的机制转化为蛋白质.
这些来自CircRNA的蛋白质在细胞功能和疾病发病过程中起着至关重要的作用.

研究的目的:

探索CircRNAs编码蛋白质的机制.
研究CircRNA编码蛋白质的生物功能.
评估CircRNA编码蛋白质作为癌症诊断标记物和治疗点的潜力.

主要方法:

关于CircRNA转换的最近研究的文献综述.
对CircRNA生物发生和蛋白质编码潜力的分析.
检查CircRNA编码蛋白在瘤发生和免疫调节中的作用.

主要成果:

循环RNA利用内部核糖体进入点,N6-甲基氨酸和滚动循环翻译来生产蛋白质.
编码的蛋白质可以调节同类的线性蛋白质和信号通路.
循环RNA及其编码的蛋白质参与瘤的进展,入侵,转移和免疫反应.

结论:

阐明CircRNA编码蛋白的表达和功能对于理解癌症生物学至关重要.
这些蛋白质代表了癌症诊断的有希望的新生物标志物.
向CircRNA编码的蛋白质可能为癌症治疗提供创新的治疗策略.

关键词:

圆形的RNARNA是一个圆形的RNA.内部核糖体的入口部位是内部核糖体.蛋白质蛋白质是蛋白质蛋白质的组成部分.蛋白质的诱是蛋白质的诱.

更多相关视频

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

相关概念视频

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Mechanisms of Retrovirus-induced Cancers

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...

Leaky Scanning

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...

The Ras Gene

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...

The Nucleolus

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...