和维生素D补充剂与创伤性SCI患者骨折的关联
Brian Le1,2, Hongyan Nathan Xu3, Frances M Weaver4,5
1Charlie Norwood Veterans Administration Medical Center, Augusta, Georgia.
Topics in spinal cord injury rehabilitation
|March 4, 2024
概括
和维生素D补充剂显著降低了脊髓损伤 (SCI) 患者骨折风险. 这支持了推这些营养素用于SCI患者骨健康的指南.
科学领域:
- 整形外科和康复治疗
- 骨健康研究 骨健康研究
- 临床流行病学临床流行病学
背景情况:
- 骨质疏松性骨折在脊髓损伤 (SCI) 患者中很普遍,增加了发病率和死亡率.
- 目前的指导方针建议和维生素D有助于骨健康,但它们对SCI骨折风险的直接影响尚未得到充分证实.
研究的目的:
- 调查和维生素D补充剂的填写处方与患有SCI的退伍军人骨质疏松性骨折风险之间的关联.
主要方法:
- 从2014财年到2020财年,对5897名患有创伤性SCI (持续时间≥2年) 的退伍军人进行了跟踪.
- 记录了上肢和下肢骨折的事件.
- 分析了或维生素D的填写处方 (≥6个月,≥80%的遵守率).
主要成果:
- 填充处方与35%的骨折风险降低有关 (HR 0.65;95% CI,0.54至0.78).
- 填充的维生素D处方显示,骨折风险降低了67% (HR 0.33;95% CI,0.29-0.38).
结论:
- 补充和维生素D与SCI的退伍军人骨折风险降低有关.
- 这些发现支持现有的指导方针,强调和维生素D对于维持SCI患者骨健康的重要性.
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