肝酶作为COVID-19患者死亡率的预测因素? 一个横截面研究
Mansour Abbasi1, Babak Choobi Anzali2, Hamid Reza Mehryar2
1Department of Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Toxicology reports
|March 4, 2024
概括
高水平的肝酶,阿斯巴酸氨基转移酶 (AST) 和氨基转移酶 (ALT),与住院COVID-19患者的更糟糕的结果有关. 监测这些酶可以帮助预测预后并指导护理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- COVID-19 感染可以通过直接的病毒效应,免疫反应,缺氧和药物毒性引起肝损伤.
- 肝功能障碍是重症COVID-19患者的一个重大问题,可能导致肝衰竭.
- 了解肝酶和COVID-19预后之间的关系对于患者管理至关重要.
研究的目的:
- 研究血清肝酶 (AST和ALT) 与住院COVID-19患者的预后之间的相关性.
- 为了比较康复和已死亡的COVID-19患者的肝酶水平.
- 为了确定是否升高的AST和ALT水平可以作为COVID-19中预后不佳的指标.
主要方法:
- 对住院COVID-19患者进行了一项描述性分析性研究.
- 从医疗记录中提取了患者数据,包括人口统计数据,血清AST和ALT水平以及结果 (恢复/死亡率).
- 统计分析比较了已康复和已死亡患者组之间的肝酶水平.
主要成果:
- 与康复患者相比,已死亡的COVID-19患者的AST (P <0.033) 和ALT (P <0.015) 的平均水平显著更高.
- 升高的AST水平与COVID-19患者的死亡率增加显著相关.
- 升高的ALT水平也与COVID-19患者的死亡率增加显著相关.
结论:
- 在COVID-19患者中血清AST和ALT水平较高可能表明预后更差,死亡风险更高.
- 在预后不佳的患者中,对肝酶的持续监测可以促进并发症的早期识别和管理.
- 积极监测肝酶可能有助于预防严重的结果,并减少COVID-19患者的死亡率.
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