在接受口服克拉迪宾治疗的多发性硬化症患者中,对免疫细胞子集和自身活性有持续的影响
Rikke Holm Hansen1, Marina Rode von Essen1, Mie Reith Mahler1
1Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.
Frontiers in immunology
|March 4, 2024
概括
克拉迪片在治疗的第二年内维持和增强了对多发性硬化症 (MS) 患者的积极作用. 这种疗法减少了有害的T和B细胞反应和自我反应,改善了MS的治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 神经免疫学 神经免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
- 克拉迪片为复发性复发性多发性硬化症 (RRMS) 提供了有效的治疗选择.
- 之前的研究表明,克拉迪宾会损害T和B细胞交叉交互,并在一年后降低自身活性.
研究的目的:
- 纵向分析在RRMS患者中治疗克拉德里宾的持续作用.
- 为了确定一年后观察到的免疫效应是否在第二年保持,调节或放大.
主要方法:
- 一项病例控制研究通过流细胞计测量了外围T和B细胞子集和B细胞细胞因子生产.
- 使用FluoroSpot测定在未经治疗和克拉迪宾治疗的RRMS患者中评估了自身活性.
- 在治疗开始后的52,60,72和96周收集的数据.
主要成果:
- 克拉迪宾治疗导致循环记忆B细胞和亲炎性B细胞反应显著减少.
- 在52周和96周观察到T细胞对自身抗原 (RASGRP2,a-B晶体) 的反应减少.
- 治疗96周后,对髓抗原 (MBP,MOG) 的反应进一步下降.
结论:
- 一年后观察到的克拉迪宾的有益免疫效应持续到治疗的第二年.
- 一些影响,包括减少对特定抗原的自身反应,在第二年得到放大.
- 克拉迪布林片在调节RRMS患者的免疫反应方面表现出持久的疗效.
相关概念视频
01:23Cells of the Adaptive Immune Response
986
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
986
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
163
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
163
01:24T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
01:29Autoimmune Disorders
434
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
434
01:24B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K