使用圣巴巴拉无形-16改性Al (SBA-16-Al) 进行里法素吸附和释放研究,用于药物输送系统
Maria Christina Prihatiningsih1, Chaidir Pratama2, Noor Anis Kundari1
1Polytechnic Institute of Nuclear Technology, National Research and Innovation Agency (BRIN) Yogyakarta Indonesia maria.christina@polteknuklir.ac.id mari003@brin.go.id.
RSC advances
|March 4, 2024
概括
改性圣巴巴拉无-16 (SBA-16-Al) 作为结核病治疗的有效里法素基因组. 这种中孔性材料具有出色的吸附和受控释放特性,可增强药物输送.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 制药科学 制药科学
背景情况:
- 结核病 (TB) 仍然是一个重大的全球卫生挑战,需要先进的药物输送系统.
- 半孔材料为药物封装和受控释放提供了有前途的平台.
- 这些材料的表面修改可以提高它们的治疗效果.
研究的目的:
- 开发和描述一种改性SBA-16 (SBA-16-Al) 矩阵,用于利芬素的输送.
- 为了研究从SBA-16-Al矩阵中Rifampicin的吸附和释放动力学.
- 评估SBA-16-Al作为结核病治疗药物载体的潜力.
主要方法:
- 使用直接合成接种方法对SBA-16表面进行修改.
- 使用FTIR,XRD,TEM和BET表面积分析对SBA-16-Al的表征.
- 批量研究以确定利芬素吸附异温和释放动力学.
主要成果:
- SBA-16-Al具有很大的表面积 (843.5 m2/g) 和纳米尺寸的毛孔.
- FTIR证实成功将合金纳入SBA-16结构 (802厘米-1的Al-O键).
- 利芬素吸附遵循弗洛伊德利希模型 (异质,多层吸附) 并被确定为稳定的化学吸附.
- 利芬素释放动力学在不同的pH值下遵循希古奇模型.
结论:
- SBA-16-Al是利法素的合适基因,表现出有效的吸附和受控释放.
- 该材料的特性表明,有可能开发改进的结核病药物输送系统.
- 需要进一步的体内研究来证实治疗疗效.
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