绘制全球研究格局和自身免疫性脑炎的发展趋势:一个图书统计分析
Song Ouyang1,2, Zhenchu Tang3,4, Weiwei Duan5
1Department of Neurology, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, PR China.
Heliyon
|March 4, 2024
概括
本次对自身免疫性脑炎 (AE) 研究的文献分析揭示了关键趋势和有影响力的贡献者. 未来的方向强调诊断,临床表现和AE的个性化免疫疗法.
科学领域:
- 神经免疫学 神经免疫学
- 神经学 神经学
背景情况:
- 自身免疫性脑炎 (AE) 是一种神经自身免疫性疾病,其特征是针对神经抗原的抗体.
- 近年来,关于AE的临床方面,治疗方法和结果的研究激增.
研究的目的:
- 进行对自身免疫性脑炎 (AE) 研究的文献分析.
- 确定AE领域的研究热点和趋势.
主要方法:
- 对1999年至2022年间发表的3348篇与AE相关的文章进行了图书统计分析.
- 分析的数据包括国家,机构,作者,参考文献,期刊和关键词.
主要成果:
- 美国,中国和德国在出版方面领先. 顶级机构包括牛津大学和宾夕法尼亚大学.
- 詹姆斯·达尔马乌 (J. Dalmau) 和阿里·文森特 (A. Vincent) 是非常富有成果的作家. 关键词包括"自身免疫性脑炎"",抗体"",NMDA受体脑炎"",边缘性脑炎".
- 最近的研究重点是NMDAR和边缘性脑炎诊断和免疫治疗.
结论:
- 发达国家主导AE研究,中国显示出产量不断增加,但需要提高质量.
- 未来的AE研究应该专注于临床表现,患病率,预后以及向免疫疗法的有效性和安全性.
相关概念视频
Enzyme-Linked Immunosorbent Assay
13.0K
In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen. Enzyme-substrate reaction allows the antigen to be visualized or...
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen. Enzyme-substrate reaction allows the antigen to be visualized or...
13.0K
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K


