在美国,肌痛性骨髓灰质炎的流行病学
Yun Ye1, Dana Jorgensen Murdock2, Chao Chen2
1The Division of Epidemiology, The Ohio State University, Columbus, OH, United States.
Frontiers in neurology
|March 4, 2024
概括
更新的美国数据显示,肌痛性骨髓灰质炎 (MG) 发病率和患病率有所增加,特别是在老年男性中. 这种罕见的自身免疫性疾病影响神经肌肉突触,目前全国约有82,715名成年人受到影响.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 全球研究表明,肌痛性骨髓灰质炎 (MG) 的患病率正在上升,这是一种罕见的自身免疫神经肌肉结合障碍.
- 美国近两十年来一直缺乏最新的流行病学数据.
- 这项研究解决了在美国人口中更新MG的流行率和发病率的需要.
研究的目的:
- 为了估计目前的发生率和发病率的肌痛性肌痛症 (MG) 在一个大,保险的美国人口.
- 为美国提供MG的最新流行病学数据.
- 分析MG发病率和流行率的特定年龄和性别趋势.
主要方法:
- 一项基于人口的回顾性队列研究使用Truven Health MarketScan数据库 (2017) 进行.
- 在商业保险,医疗保险和医疗补助人口中,使用经过验证的算法识别了MG病例.
- 根据年龄和性别标准化估计,计算并推断到2021年美国成年人口.
主要成果:
- 年龄和性别标准化的发病率为68.5个新病例/百万人年,在商业/医疗保险人群中,流行率为316.4个/百万.
- 调整后的发病率为4970万人/年,在医疗补助人口中,患病率为2037万人/年.
- 据估计,2021年约有82,715名美国成年人患有MG,随着年龄的增长和老年人群中男性占优势的转变,患病率越来越高.
结论:
- 更新的美国估计显示,与20年前相比,MG的发病率和流行率增加了.
- 这些发现与工业化国家观察到的趋势一致.
- 随着年龄的增长,特别是老年男性的患病率增加,需要进一步研究基础研究,治疗方法和公共卫生策略.
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