青少年社会压力引起的质子甲基化变化调节了mPFC中的休息状态活动
Jiesi Wang1, Wei Zhang1,2, Hang Xu1
1CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Research (Washington, D.C.)
|March 4, 2024
概括
早期的压力会通过表观遗传变化改变大脑功能和行为. 在中部前额叶皮层中,质子的修改会影响静止状态的活动,为压力诱导的行为变化提供了分子基础.
科学领域:
- 神经科学是一个神经科学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子精神病学分子精神病学
背景情况:
- 早期的生活压力 (ELS) 导致大脑功能和表观遗传修饰的持久变化.
- 连接ELS,表观遗传变化和改变的大脑活动的分子机制仍然不清楚.
- 压力引起的表观遗传修饰往往是全球性的,影响多个基因和大脑区域.
研究的目的:
- 研究青少年社会压力 (ASS) 后表观遗传修饰和区域静止状态大脑活动之间的关系.
- 测试全球表观遗传变化调节静止状态大脑功能并影响行为的假设.
主要方法:
- 利用一个小鼠模型的青少年社会压力 (ASS).
- 使用休息状态功能磁共振成像 (rs-fMRI) 来评估大脑活动.
- 在中部前额皮质 (mPFC) 中测量了素H3氨酸9二甲基化 (H3K9me2) 的水平.
- 用UNC0642抑制H3K9me2并评估其对行为和大脑活动的影响.
主要成果:
- ASS小鼠表现出增加的焦虑和社会回避行为.
- 受到压力的小鼠在mPFC中显示H3K9me2水平升高和静止状态活性降低 (ALFF).
- 抑制H3K9me2与UNC0642逆转焦虑行为和增加mPFC ALFF在控制和压力小鼠.
结论:
- 这项研究在早期生活压力的背景下,建立了基斯顿修饰和rs-fMRI发现之间的联系.
- 表观遗传变化,特别是mPFC中的H3K9me2,在调节休息状态大脑功能和压力后的行为方面发挥作用.
- 提供了与压力相关疾病中观察到的rs-fMRI变化的潜在分子解释.
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