酸盐被茶/咖啡代谢物改变,与多个系统缩和帕金森病相反相关
Xu-Ying Li1,2, Teng Xue3,4, Hong Lai1
1Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, 100053, China.
Heliyon
|March 4, 2024
概括
在多个系统缩 (MSA) 中,酸盐水平下降,在帕金森病中增加.
科学领域:
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
背景情况:
- 多重系统缩 (MSA) 是一种进展性神经退行性疾病,缺乏已确定的生物标志物.
- 酸盐和乳酸盐是关键的大脑代谢物,但它们在MSA病原发生中的作用尚不清楚.
- 生活方式因素可能会影响这些代谢途径,影响疾病风险.
研究的目的:
- 调查血中酸盐和乳酸盐在MSA和帕金森病 (PD) 中的相关性和诊断价值.
- 在疾病中探索与生活方式相关的代谢物 (茶/咖啡) 和酸盐/乳酸盐之间的相互作用.
- 评估这些代谢物的诊断性能,以区分MSA,PD和健康对照 (HC).
主要方法:
- 针对性质谱法被用于测量酸盐/乳酸盐和茶/咖啡代谢物.
- 机器学习模型被用来评估诊断和区分性能.
- 统计分析评估了代谢物相关性和相互作用.
主要成果:
- 与HC相比,酸盐水平在MSA显著下降,PD增加.
- 茶/咖啡代谢物在HC中与pyruvate负相关,但在MSA或PD中没有.
- 酸盐和茶/咖啡代谢物组合可实现MSA (AUC=0.878) 和PD (AUC=0.833) 的高诊断准确度.
- 酸盐有效地将MSA与PD区分开来 (AUC=0.860),与theanine和1,3-dimethyluric acid (AUC=0.922) 结合使用时准确度提高.
结论:
- 酸盐与MSA和PD呈现反向相关性,这表明它在病变发生过程中扮演着不同的角色.
- 与生活方式相关的茶/咖啡代谢物可能会改变pyruvate在这些神经退行性疾病中的作用.
- 代谢物概况为MSA和PD提供了有前途的诊断和差异化潜力.
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