作为预测HBV相关脱补偿性肝硬化预后的新型指标,D-二聚体与血小板计数比率
1Department of Clinical Laboratory, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, 312400, China.
Heliyon
|March 4, 2024
概括
D-二聚体与血小板计数比率 (DPR) 可以预测乙型肝炎病毒相关的无补偿性肝硬化 (HBV-DC) 的死亡率. 升高的DPR是HBV-DC患者30天死亡的独立风险因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床医学 临床医学
- 生物标志物研究 生物标志物研究
背景情况:
- 与乙型肝炎病毒相关的失补偿性肝硬化 (HBV-DC) 由于低生存率而构成重大挑战.
- 准确的预后指标对于有效的患者风险分层和管理至关重要.
研究的目的:
- 评估D-二聚体与血小板计数比率 (DPR) 作为HBV-DC患者30天死亡率的预后生物标志物.
- 评估DPR的预测性能与末期肝病模型 (MELD) 评分相比.
主要方法:
- 对164名HBV-DC患者的病历进行了回顾性分析.
- 多变量后勤回归和ROC曲线分析以确定DPR对30天死亡率的预测值.
- 将DPR的预测准确度与MELD得分进行比较.
主要成果:
- 总共有30名 (18.3%) 患者在30天内死亡.
- 较高的DPR值与死亡率的增加显著相关;DPR是一个独立的风险因素 (OR=1.017,p=0.003).
- DPR的AUC达到0.762,相当于MELD得分 (AUC=0.762,p=0.100);联合使用改善了AUC到0.897.
结论:
- 升高的DPR与HBV-DC患者的不良结果相关.
- DPR显示出作为评估HBV-DC预后的有效生物标志物的潜力.
- 将DPR与MELD得分相结合,可以提高死亡率预测的准确性.
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