放射常见的间歇性肺炎模式与异常性肺纤维化患者的两年死亡率有关
Ignacio Gayá García-Manso1, Juan Arenas Jiménez2, Luis Hernández Blasco1,3
1Department of Pulmonology, Dr. Balmis General University Hospital, ISABIAL, Alicante, Spain.
Heliyon
|March 4, 2024
概括
患有常见间歇性肺炎 (UIP) 模式的异形性肺纤维化 (IPF) 患者的死亡率高于可能患有UIP的患者. 放射学发现,如蜂预测IPF的生存率更差.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 对异常性肺纤维化 (IPF) 的新诊断指南允许将通常的间歇性肺炎 (UIP) 和可能的UIP放射性模式结合起来.
- 在IPF中这些独特的放射性模式的预后影响仍然不清楚,研究结果各不相同.
研究的目的:
- 在IPF患者中评估UIP和可能的UIP放射学模式之间的生存差异.
- 确定IPF中死亡率的放射学预测因素.
主要方法:
- 从146名IPF患者的高分辨率计算机断层扫描 (HRCT) 图像的回顾性分析.
- 两个胸部放射科医生审查了HRCT图像,以查看放射学模式和发现.
- 分析了放射性模式/发现与两年死亡率的关联.
主要成果:
- 在UIP模式下,两年死亡率为40.2%,而可能的UIP则为7.1%.
- 可能的UIP对死亡率 (HR 0.23,95% CI 0.06-0.99) 有保护作用,即使经过调整.
- 蜂 (HR 3.62),急性恶化模式 (HR 4.07) 和纤维化程度 (HR 1.04) 预测死亡率.
结论:
- 患有UIP模式的IPF患者的两年死亡率高于可能患有UIP的患者.
- 放射学发现包括蜂,急性恶化模式和纤维化程度预测死亡率.
- 保持不同的UIP和可能的UIP模式是由观察到的预后差异支持的.
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