温度异常对精子质量的影响:对33234名男性的多中心研究
Lina Xiao1, Qiling Wang2,3, Haobo Ni1
1Department of Preventive Medicine, Shantou University Medical College, Shantou, 515041, China.
Heliyon
|March 4, 2024
概括
全球温度异常 (TA) 通过降低精子质量,对男性生育能力产生负面影响. 极端的高温和低温都会影响精子度,数量和运动性,这强调了减少接触异常温度的必要性.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 流行病学 流行病学
背景情况:
- 全球生育率正在下降,男性因素扮演着重要的角色.
- 精子质量是男性生育能力的关键决定因素.
- 以前的研究将极端温度与精子质量降低联系在一起,但缺乏对长期适应性的分析.
研究的目的:
- 为了研究温度异常 (TA) 和男性精子质量之间的暴露-反应关系.
- 评估长时间的热和冷适应对精子参数的影响.
- 分析从长期气候模式和生育指标的偏差之间的关联.
主要方法:
- 一项多中心的回顾性队列研究,涉及来自中国33,234名捐献者的78,952个精液样本.
- 对精子质量参数的分析,包括热季和寒季的度,数量和运动率.
- 应用线性混合和通用线性模型进行元分析,以确定TA的聚合效应.
主要成果:
- 在炎热的季节,在TA和精子质量之间观察到一个反转的U形关系.
- 在炎热的季节异常感冒对精子质量产生了显著的负面影响,即使在调整了BMI,婚姻状况和生育史之后.
- 与热量相关的TA对精子度,进展性精子数和总运动精子数 (P<0.05) 有负面影响. 在湿度调整后,与寒冷相关的TA对精子总运动有负面影响 (P<0.05).
结论:
- 与热和冷相关的温度异常都与精子质量下降有关.
- 这些发现强调了减少暴露于异常温度的重要性,以保护男性生育能力.
- 这项研究提供了关于气候变化对生殖健康影响的流行病学证据.
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