骨肌肉评估在患有巨症的患者
Angelo Milioto1, Giuliana Corica1, Federica Nista1
1Endocrinology Unit, Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa 16138, Italy.
Journal of the Endocrine Society
|March 4, 2024
概括
壮症患者的肌肉质量没有增加,而是肌肉质量和体力表现下降. 需要进一步的研究,才能充分理解骨肌肉在壮症中的变化.
科学领域:
- 内分泌学 在内分泌学.
- 肌肉生理学 肌肉生理学
背景情况:
- 巨症涉及慢性高生长激素 (GH) 和胰岛素样生长因子-1 (IGF-1) 的水平.
- 这些激素具有合成代谢效应,表明可能增加骨肌肉质量.
研究的目的:
- 系统地审查骨肌肉质量,质量和壮症患者的表现的证据.
- 综合了与健康个体相比,壮症患者肌肉特征的研究结果.
主要方法:
- 在PubMed的系统文献综述,截至2023年9月1日.
- 搜索术语:壮症 和 ("肌肉质量"或"骨肌肉").
- 包括比较疾病状态的研究;不包括除生物电阻分析外的非放射学方法.
主要成果:
- 包括15项研究 (360名患者进行质量,122名患者进行脂肪缩,192名患者进行表现).
- 没有明确的证据表明,在活跃的壮症中,骨肌肉质量增加.
- 在壮病患者中,脂肪透率较高的趋势和持续较差的身体表现.
结论:
- 壮症患者的骨肌质量和表现低于健康个体.
- 由于研究的局限性和混因素,肌肉质量的结果各不相同.
- 需要进行前性研究,以澄清壮病中的骨肌肉质量.
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