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Updated: Jul 1, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

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CDK6蛋白表达与多发性髓瘤的疾病进展和治疗耐药性有关

Johannes Steinhart1,2, Peter Möller1, Miriam Kull2

  • 1Department of Pathology Ulm University Hospital Ulm Germany.

HemaSphere
|March 4, 2024
PubMed
概括

循环素依赖性激酶6 (CDK6) 在多发性骨髓瘤 (MM) 中升高,与疾病进展和药物耐药性有关. 在MM患者中增加CDK6表达与较短的无进展生存相关,特别是在莱纳利多米德治疗后.

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Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants07:39

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

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Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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