中国心脏代谢风险因素的参考间隔:在成年人群样本上进行的国家多中心横截面研究
Xuesong Fan1, Xianjun Wang2, Hongmei Zhao3
1Department of Clinical Laboratory Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
这项研究确定了中国成年人血液脂质和葡萄糖的准确,年龄和性别特定的参考间隔. 这些新的参考值将有助于诊断和管理心血管疾病.
科学领域:
- 临床化学 临床化学
- 生物统计学 生物统计学
- 公共卫生 公共卫生
背景情况:
- 目前对中国成人血脂的参考间隔缺乏当地人口数据和对年龄和性别的调整.
- 现有的间隔可能不准确地反映中国成年人口的健康状况.
研究的目的:
- 在中国成年人中确定精确的,年龄和性别特定的血脂参数和血糖 (GluG) 参考间隔.
- 为心血管疾病 (CVD) 的临床诊断和管理提供可靠的基础.
主要方法:
- 一项全国性的多中心研究,涉及11333名年龄在18-90岁的中国成年人.
- 从七个代表性地区收集的数据,用自动化生化分析仪集中分析样本.
- 统计分析包括异常值去除 (图基测试),差异分析,百分点曲线的LMS方法和参考区间确定非参数方法.
主要成果:
- 在不同中国城市观察到小密度低密度脂蛋白胆固醇 (sd-LDLC),GluG和阿波蛋白A1 (ApoA1) 的区域差异.
- 在同等氨酸 (HCY),高密度脂蛋白胆固醇 (HDLC) 和ApoA1水平中发现了基于性别的显著差异.
- 随着年龄的增长,血糖和HCY水平增加,在45-55岁和55岁以上的女性中,甘油三 (TG) 和总胆固醇 (TC) 的显着变化.
结论:
- 该研究成功地确定了中国成年人血液脂质和葡萄糖的年龄和性别特定参考值.
- 这些发现对于改善中国心血管疾病 (CVD) 的查,诊断,治疗和监测至关重要.
- 建立的参考间隔为临床医生和研究人员在心血管健康领域提供了一个至关重要的工具.
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