对药剂师主导的药物审查的药物安全性评估工具的评估:东欧试点项目
Anita Tuula1, Piotr Merks2, Magdalena Waszyk-Nowaczyk3
1Institute of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, Estonia.
Frontiers in pharmacology
|March 4, 2024
概括
东欧的药剂师主导的药物审查 (MR) 在多药店患者中发现了与药物有关的重大问题. 虽然安全性评估工具有助于审查,但它们补充了,而不是取代了患者访谈和监测,以获得最佳的药物安全性.
科学领域:
- 老年人药房 老年人药房
- 药物安全 药物安全
- 社区药房实践 社区药房实践
背景情况:
- 药剂师主导的药物审查 (MR) 对于管理多药店和提高药物安全至关重要.
- 这项研究试点在东欧社区药房进行MR,以评估多药房患者的药物使用和安全工具.
研究的目的:
- 在东欧社区药房试点药剂师主导的药物审查 (MR).
- 描述多药患者药物使用模式.
- 评估药物安全评估工具的可用性和有效性.
主要方法:
- 一项试点研究涉及6个东欧国家的318名多药房患者 (≥5种药物).
- 药剂师进行了结构化采访,以收集有关药物相关问题 (DRP) 和药物遵守的数据.
- 对于潜在的药物相互作用 (pDDI) 和药物不良反应 (ADR),并用于潜在不合适药物 (PIM) 的综合工具 (EU(7) -PIM/EURO-FORTA) 的追溯分析使用了数据库 (Inxbase/Riskbase).
主要成果:
- 56.6%的患者经历了504次pDDI (平均1.6/患者),其中5.0%的高风险.
- 87.7%的人有潜在的副作用 (20.8%的高风险);27个pDDI和68个已识别的副作用没有在数据库中.
- 96%的老年患者 (≥65岁) 使用PIM (平均3.4/患者),其中29.6%使用高风险PIM,其中一些被记录为DRP.
结论:
- 药物安全性评估工具是药物审查中的有价值的辅助工具,但不能取代临床判断和患者互动.
- 提供明确风险解释和用户友好性的工具提高了药物审查的有效性.
- 药剂师主导的药物审查对于识别和管理多药房患者复杂的药物相关问题至关重要.
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