循环德克斯金属有机框架作为一种药物输送系统,用于精选的活性药物成分
Kristi Ne Kru Kle-Be Rziṇa1, Alons Lends1, Anna Boguszewska-Czubara2
1Latvian Institute of Organic Synthesis, Aizkraukles iela 21, Riga LV-1006, Latvia.
ACS omega
|March 4, 2024
概括
基于环氧的金属有机框架 (CD MOF) 提供安全的药物输送. 研究人员发现,gCD-K-5 MOFs有效封装药物,减少对正常细胞的毒性并增强生物相容性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 制药科学 制药科学
背景情况:
- 基于环氧的金属有机框架 (CD MOF) 是药物输送的有希望的平台,因为毒性低和成本效益高的合成.
- 在CD MOF中封装活性药物成分 (API) 可以提高其治疗疗效和安全性.
研究的目的:
- 通过使用 γCD-K MOF 模型系统,研究卡莫 (HCFU),5-甲酸 (5-FU) 和酸 (HBA) 的宿主-客人封装方法.
- 描述API:CD MOF复合体中的结构和相互作用.
- 评估开发的装有药物的CD MOFs的体外和体内毒性和生物相容性.
主要方法:
- 使用各种结晶协议进行主机-客户端封装.
- 包括液态染色体质谱法 (LC-MS),微分扫描热量计 (DSC),热重力测量分析 (TGA) 和固态NMR光谱法 (ssNMR) 在内的特征化技术.
- 在体外细胞毒性,肝毒性和神经毒性测定中使用纤维细胞 (BJ),HepG2和MO3.13细胞系.
- 在体内生态毒性研究使用Danio rerio (斑马鱼).
主要成果:
- 在API:CD MOF复合体内进行结构确认和相互作用位点识别.
- 证明了封装药物的细胞毒性,肝毒性和神经毒性的降低.
- γCD-K-5被确定为药物封装的最佳MOF,显示对正常细胞的保护作用.
结论:
- γCD-K-5 MOF是封装HCFU,5-FU和HBA等API的安全有效平台.
- 开发的药物输送系统显著降低了API对正常细胞的毒性,并且具有良好的生物相容性.
- 这项研究强调了CD MOFs在开发更安全,更有效的药物配方方面的潜力.
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