杀死接触的抗菌聚乙烯聚合物使用四分化阴离子启动器聚合
Akiko Jitsuhiro1, Tomoki Maeda2,3, Akiko Ogawa1
1Kirin Central Research Institute, Kirin Holdings Company Limited, 26-1 Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555 Japan.
ACS omega
|March 4, 2024
概括
研究人员使用阴离子启动器开发了一种新的接触杀死抗菌聚乙烯 (PS) 板. 这种材料表现出持续的,广泛的抗菌活性,在洗后仍然有效,为传统抗菌剂提供了有希望的替代品.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 抗微生物技术 抗微生物技术
背景情况:
- 接触杀伤性抗菌材料提供持续的有效性,但对于像聚钢 (PS) 这样的稳定聚合物来说,其开发具有挑战性.
- 由于其稳定的结构,聚乙烯的化学修饰是很困难的,这限制了有效的抗菌表面的发展.
- 现有的抗菌剂,如银,通常是可浸的,在洗时失去活性.
研究的目的:
- 开发一种具有持续活性的抗菌聚钢板,可以杀死接触物.
- 调查表面电离性质在抗菌功效中的作用.
- 评估材料对抗各种细菌的性能,包括耐药菌株,以及洗后的耐用性.
主要方法:
- 合成的聚乙烯使用2.2'--[2-(1,3-二甲基-4,5-二-1H-imidazol-3--2-yl) ]三酸盐 (ADIP) 作为一个激素启动剂.
- 描述了合成聚乙烯 (ADIP-PS) 的表面特性,包括 ζ-潜在.
- 在洗前和洗后对包括耐药菌株在内的格拉姆阳性和格拉姆阴性细菌进行抗菌活性评估.
- 在L929细胞上进行了细胞毒性测试.
主要成果:
- 与ADIP (ADIP-PS) 合成的聚乙烯表现出显著的接触杀死抗菌活性,与与其他启动剂合成的聚乙烯不同.
- ADIP-PS具有阴离子表面,由z-电位测量证实,这与其抗菌特性相关.
- 洗后,ADIP-PS保持了抗菌活性,性能优于含银的聚钢,并证明了对各种细菌的广泛疗效.
- 细胞毒性测试表明,ADIP-PS表是非细胞毒性的.
结论:
- 开发的ADIP-PS材料提供了有效和耐用的接触杀死抗菌表面.
- 由ADIP发起者传递的阴性性质对于该材料的持续抗菌活性至关重要.
- ADIP-PS为各种应用提供了一个有希望的,易于生产的,无毒的抗微生物材料.
相关概念视频
Anionic Chain-Growth Polymerization: Overview
2.1K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
2.1K
Cationic Chain-Growth Polymerization: Mechanism
2.3K
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
2.3K
Radical Chain-Growth Polymerization: Overview
2.4K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
2.4K
Anionic Chain-Growth Polymerization: Mechanism
2.0K
The mechanism for anionic chain-growth polymerization involves initiation, propagation, and termination steps. In the initiation step, a nucleophilic anion, such as butyl lithium, initiates the polymerization process by attacking the π bond of the vinylic monomer. As a result, a carbanion, stabilized by the electron‐withdrawing group, is generated. The resulting carbanion acts as a Michael donor in the propagation step and attacks the second vinylic monomer, which acts as a Michael...
2.0K
Radical Chain-Growth Polymerization: Mechanism
2.5K
The radical chain-growth polymerization mechanism consists of three steps: initiation, propagation, and termination of polymerization. The polymerization initiates when a free radical generated from the radical initiator adds to the unsaturated bond in the monomer. The unpaired electron of the free radical and one π electron in the unsaturated bond creates a σ bond between the free radical and the monomer. As a result, the other π electron in the unsaturated bond converts this...
2.5K
Free-Radical Chain Reaction and Polymerization of Alkenes
7.8K
The conversion of alkenes to macromolecules called polymers is a reaction of high commercial importance. The structure of the polymer is defined by a repeating unit, while the terminal groups are considered insignificant. The average degree of polymerization represents the number of repeating units in the polymer molecule and is denoted by the subscript n.
7.8K


