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循环中的微量营养素水平及其与败血症易感性和严重性的关联:孟德尔的随机化研究
Zhengxiao Wei1, Yingfen Liu1, Xue Mei2
1Department of Clinical Laboratory, Public Health Clinical Center of Chengdu, Chengdu, Sichuan, China.
Frontiers in genetics
|March 4, 2024
概括
基因预测的水平可能会降低严重败血症相关死亡的风险. 这项孟德尔随机化研究表明,补充剂可能有利于高风险败血症患者,需要进一步调查.
科学领域:
- 遗传学和精准医学 遗传学和精准医学
- 营养流行病学 营养流行病学
- 临界护理医学 临界护理医学
背景情况:
- 败血症是一个关键的全球健康问题,需要了解可修改的因素.
- 微量营养素在败血症发病过程中的作用及其遗传联系尚不清楚.
- 识别对微量营养素水平的遗传影响可以提供有关败血症风险的见解.
研究的目的:
- 调查基因预测的微量营养素水平与败血症之间的因果关系.
- 评估九个关键微量营养素 (,β-胡卜素,铁,,,维生素C,维生素B6,维生素D,) 对败血症易感性,严重性和特定亚型的影响.
- 探索这些微量营养素在败血症结局中的潜在保护性或有害影响.
主要方法:
- 孟德尔随机化 (MR) 分析使用遗传变异作为循环微量营养素水平的仪器变量进行.
- 利用了针对微量营养素和败血症的大型全基因组关联研究 (GWAS) (英国生物银行,FinnGen) 的总结统计数据.
- 为了确保稳定性,进行了初级MR分析,元分析,针对特定败血症结果的二次MR分析和灵敏度分析.
主要成果:
- 在基因预测较高的水平和28天内严重败血症相关死亡风险降低之间发现了显著的因果关系 (OR=0.450).
- 有关证据表明,铁可能会增加败血症风险,β-胡卜素可能会降低败血症死亡风险,而维生素C可能会降低产后败血症风险.
- 没有发现,,,维生素B6或维生素D与败血症结局的显著因果关系.
结论:
- 作为一种潜在的保护因素,可以防止严重败血症相关的死亡率.
- 这些发现提供了基因基础,支持补充剂在高风险的重症败血症患者的潜在益处.
- 建议进行更大规模的研究,以验证这些微量营养素与败血症的关联,并为临床实践提供信息.
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