有机污染物暴露和CKD:慢性功能衰竭队列试点研究
David M Charytan1, Wenbo Wu1,2,3, Mengling Liu2,3
1Division of Nephrology, Department of Medicine, New York University Grossman School of Medicine, New York, New York.
Kidney medicine
|March 4, 2024
概括
暴露于某些有机污染物,特别是酸盐,可能会加速慢性病 (CKD) 的成年人功能下降. 这项研究测量了慢性病患者随时间推移的污染物水平.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 毒理学 毒理学 毒理学
背景情况:
- 慢性病 (CKD) 影响全球数百万人,环境因素可能有助于其进展.
- 了解有机污染物对功能的影响对于公共卫生和临床管理至关重要.
研究的目的:
- 评估暴露于各种有机污染物和患有CKD的成年人功能下降之间的关联.
- 为了研究特定化学品类,包括酸盐和双,对估计的淋巴细胞过率 (eGFR) 轨迹的纵向影响.
主要方法:
- 对40名慢性功能缺陷队列 (CRIC) 的成年人进行了横截面和纵向分析.
- 在1,3年和5年,用高性能液体色谱与联质谱测量,测量了双,酸盐,有机酸农药,多环芳,胺和酸的尿度.
- 统计分析包括后勤回归和Cox比例危险模型,以检查污染物暴露与临床结果之间的关联,包括eGFR下降.
主要成果:
- 在52种测量的有机化合物中,有30种可以在50%以上的参与者中检测到,其水平与健康个体相似.
- 甲酸盐在CKD患者中显示出更高暴露的趋势.
- 在暴露于双F,特定酸盐 (单3-碳烯基酸盐,单酸盐,单酸盐,单酸盐) 和有eGFR斜率的胺之间观察到一个反向关系,这表明功能恶化更快.
结论:
- 在患有CKD的成年人中同时测量多种有机污染物是可行的,暴露水平与健康人群相当.
- 特定的有机污染物,特别是酸盐,可能与慢性病患者的功能加速下降有关.
- 需要进一步的研究来评估联合暴露及其对CKD进展的影响.
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