农药暴露和肺癌风险:泰国纳洪萨万的一个病例对照研究
Teera Kangkhetkron1,2, Chudchawal Juntarawijit3
1Department of Natural Resources and Environment, Faculty of Agriculture, Natural Resources and Environment, Naresuan University, Phitsanulok, 65000, Thailand.
F1000Research
|March 4, 2024
概括
包括除草剂和杀虫剂在内的农药暴露与肺癌风险增加有关. 在这项病例控制研究中,迪尔德林, хлорпирифос, карбофуран, глифосат和帕拉克瓦特被确定为显著的危险因素.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 农药暴露是肺癌的潜在环境风险因素.
- 了解农药使用与肺癌之间的具体联系对于公共卫生至关重要.
- 这项研究解决了研究的差距,因为大多数出版物来自西方国家.
研究的目的:
- 调查历史农药使用与肺癌之间的关联.
- 确定与肺癌风险增加相关的特定类型和个别农药.
主要方法:
- 采用病例控制研究设计,将233例肺癌病例与447例匹配的健康对照进行了比较.
- 通过面对面的采访收集了有关终身农药暴露,人口统计和其他风险因素的数据.
- 使用后勤回归分析来评估关联,并对吸烟和空气污染等混因素进行调整.
主要成果:
- 肺癌与终身使用除草剂和杀虫剂有积极的关联.
- 对除草剂和杀虫剂的高暴露量 (Q3-Q4) 观察到肺癌风险增加.
- 对于迪尔德林, хлорпирифос, карбофуран, 草甘, 和 帕拉克瓦特, 发现了显著的关联.
结论:
- 迪尔德林和 хлорпирифос是肺癌的确诊危险因素.
- 碳素,草甘和酸盐被认为是潜在的新型风险因素.
- 需要进一步的研究来验证这些发现,并确定其他相关的农药.
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