基于瘤细胞来源的视网母细胞瘤复发的管理
Shivna K Thaker1, Parag K Shah2, Abhishek Das1
1Fellow, Observer in ROP, Pediatric Retina and Ocular Oncology, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.
Middle East African journal of ophthalmology
|March 4, 2024
概括
了解视网膜母细胞瘤 (RB) 复发模式对于管理至关重要. 痕复发 (模式2) 和新病变 (模式3) 是可挽救的,但扩散的玻璃体种子 (模式1b) 的地球挽救率很低.
科学领域:
- 眼科医生 眼科 眼科
- 儿科瘤学 儿科瘤学
- 视网膜疾病 视网膜疾病
背景情况:
- 视网母细胞瘤 (RB) 是儿童中最常见的初级眼内恶性瘤.
- 了解复发模式对于有效管理和提高全球救援率至关重要.
研究的目的:
- 描述视网膜母细胞瘤的复发模式,包括痕复发,新病变和玻璃体种子.
- 通过预测不同类型的复发结果,为未来的管理策略提供信息.
主要方法:
- 南印度45名未接受治疗的视网膜母细胞瘤患者的64只眼睛的回顾性观察研究 (2019年1月至2020年7月).
- 复发模式被分为第1模式 (玻璃状种子:局部1a,扩散1b),第2模式 (痕复发) 和第3模式 (从子皮种子的新病变).
- 患者的最低随访时间为12个月.
主要成果:
- 痕复发 (模式2) 和新病变 (模式3) 在32只眼睛中发生;所有眼睛都通过局部瘤巩固得以挽救.
- 玻璃状种子传播 (模式1) 在18只眼睛中发生;在8只眼睛中扩散传播 (模式1b),尽管进行化疗,但需要去核.
- 10只眼睛的局部玻璃体种子 (模式1a) 治愈了;用模式1a比1b更好地挽救了地球球.
结论:
- 局部瘤巩固有效地挽救了痕复发的眼睛 (模式2) 和新的病变 (模式3).
- 对于分散的玻璃体种子 (模式1b),即使进行了密集处理,球体救援率也很低.
- 通过定期,详细的视网膜检查及早发现是成功管理RB复发的关键.
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