腹腔透析患者的基线空腹血糖和死亡率之间的非线性关系,是一项回顾性队列研究
Xiang Li1, Chengjuan Fan1, Chen Wang1
1Department of Nephrology, Affiliated Hospital of Jining Medical University, Jining, China.
Frontiers in medicine
|March 4, 2024
概括
这项研究发现了基线空腹血糖 (bFBG) 与腹腔透析 (PD) 患者的死亡率之间的U形关系. 最佳bFBG的5.1mmol/L与最低的死亡风险有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 临床医学 临床医学
背景情况:
- 基线空腹血糖 (bFBG) 与腹腔透析 (PD) 患者的死亡率之间的关联仍在争论中.
- 之前的研究还没有充分探讨bFBG和这一患者群的死亡率之间的非线性关系.
研究的目的:
- 调查bFBG与PD患者死亡率之间的非线性关系.
- 确定与降低死亡风险相关的最佳bFBG值.
主要方法:
- 对379名PD患者的回顾性分析.
- 基于bFBG. 的四分位数分类.
- 使用卡普兰-梅尔曲线和COX比例危险模型进行生存分析.
- 曲线拟合和值效应分析以评估非线性.
主要成果:
- 在bFBG和死亡风险之间发现了显著的关联 (HR:1.22,95%CI:1.05-1.41,P = 0.009).
- 卡普兰-梅尔分析显示,bFBG组之间的生存率存在显著差异 (P < 0.01).
- 曲线拟合揭示了一个U形关系,折叠点约为5.1mmol/L.
结论:
- 在bFBG和PD患者的死亡率之间存在非线性,U形关系.
- 大约5.1mmol/L的最佳bFBG水平与该人群中死亡风险最低相关.
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