富含氧气可以通过增强自性来改善与年龄相关的认知障碍
Shengyuan Wang1,2,3,4, Bengang Chen2,3,4, Minghao Yuan1,2,3,4
1Chongqing Medical University, Chongqing, China.
Frontiers in aging neuroscience
|March 4, 2024
概括
高压氧疗法 (HBOT) 通过增强突触可塑性和减少病理来改善老年小鼠的认知功能. 这种干预激活了自和AMPK-mTOR通路,为与年龄相关的认知障碍提供了潜在的可能性.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物医学工程 生物医学工程
背景情况:
- 与年龄相关的认知障碍是一个日益严重的健康问题.
- 了解机制和干预措施至关重要.
- 高压氧疗法 (HBOT) 正在探索治疗潜力.
研究的目的:
- 研究老年小鼠对认知功能和神经元完整性的HBOT影响.
- 探索HBOT对基因表达的影响,重点关注突触基因.
- 阐明HBOT的好处背后的分子机制.
主要方法:
- 年龄大于C57BL/6的小鼠接受了HBOT治疗2周.
- 使用莫里斯水迷宫进行认知评估.
- 转录组测序,基因本体学分析,西部斑点和传输电子显微镜.
主要成果:
- 通过HBOT改善了空间学习和记忆.
- 调节后突触组织,突触组织和轴突发生的GO术语.
- 降低了高酸化,增加了突触蛋白 (PSD95,BDNF,Syn),增强了自 (Beclin-1,LC3),并激活了AMPK-mTOR通路.
- 海马的超结构性改善,包括突触的增加和脱髓化病变的减少.
结论:
- 在老鼠中,HBOT改善了与年龄相关的认知障碍.
- 机制包括增强的突触可塑性,减少tau病理,并通过AMPK-mTOR信号激活自.
- 在认知衰退方面,HBOT显示出治疗潜力.
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