针对高突变三阴性乳腺癌的编程死亡1-定向抗体的持久反应:一个病例报告
Emilie Platteter1, Gerburg Wulf2
1Phase One Cancer Clinical Trials, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Case reports in oncology
|March 4, 2024
概括
编程细胞死亡1抑制剂 pembrolizumab 在一个超突变的患者中有效治疗了复发的三阴性乳腺癌 (TNBC). 这种免疫瘤 (IO) 剂提供了持久的反应,没有显著的毒性.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫检查点抑制剂代表了癌症治疗的重大进步.
- 布罗利祖马布 (Keytruda) 已在治疗三阴性乳腺癌 (TNBC) 的联合治疗中取得成功.
- 有限的数据存在于TNBC的 pembrolizumab单疗法,特别是罕见的瘤突变负担.
研究的目的:
- 报告一次罕见超突变的复发性TNBC病例,该病例是用 pembrolizumab 单疗法治疗的.
- 评估pembrolizumab在这个特定患者群体中的疗效和安全性.
主要方法:
- 一个65岁的患者的病例报告,患有复发性TNBC和肺转移.
- 转移性结节的下一代测序,以确定瘤突变负担和ploidy.
- 用 pembrolizumab (编程细胞死亡 1 抑制剂) 治疗.
主要成果:
- 下一代测序揭示了一个超突变的瘤,具有罕见的多倍体性.
- 患者在14个月内实现了持久的反应和持续的缓解.
- 没有观察到与免疫检查点抑制剂相关的显著毒性或疾病进展.
结论:
- 这一案例证明了pembrolizumab单一疗法的成功使用在罕见高突变的复发性TNBC中.
- 免疫瘤学 (IO) 药物可以作为具有独特基因组形状的高级TNBC的有效治疗方法.
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