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血电解氧化用于牙科植入物表面处理
A A Muraev1, A I Murzabekov2, S Yu Ivanov3
1Professor, Department of Oral and Maxillofacial Surgery; Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., Moscow, 117198, Russia.
Sovremennye tekhnologii v meditsine
|March 4, 2024
概括
血电解氧化 (PEO) 增强牙植入物表面,以改善骨质整合. 无论是PEO-Ti和PEO-Ca治疗都显示出高潜力,PEO-Ca表现出优越的表面接触,以提高牙植入物的疗效.
科学领域:
- 生物材料科学 生物材料科学
- 牙科植入物学 牙科植入物学
- 表面工程是什么?表面工程是什么?
背景情况:
- 血电解氧化 (PEO) 是修改牙植入物表面的关键技术.
- 合金由于其生物相容性和机械性能,广泛用于牙科植入物.
- 优化植入物表面特征对于成功的骨整合和长期临床结果至关重要.
研究的目的:
- 评估两种不同的PEO表面修改技术的有效性,用于用VT1-0医用合金制成的牙科植入物.
- 为了比较PEO处理的表面与未经处理的对照样本的骨整合潜力.
- 分析PEO-Ti和PEO-Ca修饰表面之间的形态和组成差异.
主要方法:
- 牙植入物 (VT1-0合金) 被分为三个组:对照组 (磨砂表面),PEO-Ti (性电解质) 和PEO-Ca (含碳酸的基于酸的电解质).
- 用电子显微镜和能量分散式X射线光谱学分析了表面形态.
- 骨质整合在体内通过在绵羊中植入治疗和控制样本,并在2,4周和8周使用微计算机断层扫描分析检索的组织来评估.
主要成果:
- 无论是PEO-Ti还是PEO-Ca处理,都产生了高度多孔的表面,具有最佳的微粗度,用于骨质整合.
- PEO-Ti表面显示出单模孔径分布 (最大~0.23μm),而PEO-Ca显示出双模分布 (最大~1.05μm和~2.45μm).
- 两种PEO方法都显示出相似的骨整合潜力,但PEO-Ca实现了显著更好的植入物与表面接触 (49.8%),而PEO-Ti (42.4%).
结论:
- 形成PEO的植入物表面表现出优异的骨整合性质,无论使用的特定电解质成分如何.
- 由于存在,PEO-Ca表面修饰表明表面接触增强,表明骨质整合得到改善.
- 这些经PEO处理的表面显示出牙植入物应用的前景,可能包括患有骨质疏松症的患者.
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