患有非酒精性脂肪性肝病患者的循环费里丁:系统性审查和元分析
Eleftheria Makri1, Myrsini Orfanidou1, Evangelia S Makri1
1First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Journal of clinical and experimental hepatology
|March 4, 2024
概括
患有非酒精性脂肪性肝病 (NAFLD) 的患者的循环费里水平比对照人群高. 费里水平与疾病严重程度相关,这表明它有可能成为NAFLD进展的生物标志物.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床生物化学 临床生物化学
- 内部医学 内部医学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的全球健康问题.
- 循环中的费里水平越来越被认为是肝炎和肝损伤的潜在指标.
研究的目的:
- 系统地合成和分析与非NAFLD对照组相比,组织学证实NAFLD患者的循环费里丁水平的数据.
- 调查费里水平与NAFLD的严重程度之间的关联,包括简单的非酒精性脂肪肝 (NAFL) 和非酒精性脂肪肝炎 (NASH).
主要方法:
- 在PubMed,Scopus和Cochrane图书馆进行了全面的系统文献搜索.
- 一项元分析包括31项研究,数据来自5631名患者 (2929名NAFLD患者和2702名对照).
- 使用I2统计数据和使用Egger测试的出版偏差来评估异质性;元回归探索异质性的来源.
主要成果:
- 与对照组相比,NAFLD患者的循环费里水平显著更高 (SMD 1.14).
- 在NAFL (SMD0.57) 和NASH (SMD0.95) 患者和对照患者,以及在NASH和NAFL患者 (SMD0.62) 中观察到高酸蛋白.
- 超回归表明NAFLD患者的男性比例和费里水平之间存在正相关性,解释了32.7%的异质性.
结论:
- 与对照人群相比,NAFLD,NAFL和NASH患者的循环费里丁水平升高.
- 较高的费里水平似乎与NAFLD严重程度的增加有关,这需要谨慎的解释.
- 费里丁可以作为NAFLD的潜在生物标志物,但需要进一步的研究来澄清其临床实用性.
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