合成大麻素首次使用引起的卡塔托尼亚:一个案例报告
Avanti Puri1, Filippo Costanzo2, Janny Rivera1
1Psychiatry, Arnot Ogden Medical Center, Elmira, USA.
Cureus
|March 4, 2024
概括
合成大麻素可以引起严重的,即使是在第一次使用者. 这一案例凸显了未经监管的物质的风险,需要像电疗法 (ECT) 这样的密集治疗.
科学领域:
- 毒理学 毒理学 毒理学
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 合成大麻素是一种强大的精神活性物质,具有不可预测的效果.
- 它们的广泛可用性和不断变化的化学成分构成了重大的公共卫生挑战.
- 了解这些化合物的神经生物学影响对于临床管理至关重要.
研究的目的:
- 报告一例罕见的因首次使用合成大麻素而引起的白内障.
- 突出合成大麻产品的潜在危险性和不可预测性.
- 强调在不明原因的猫头的情况下考虑合成大麻素中毒的重要性.
主要方法:
- 一个32岁的女人没有大麻使用史的案例报告.
- 临床表现,高剂量洛拉泽治疗和随后的电震治疗 (ECT) 的文件.
- 关于合成大麻素毒性和catatonia的文献综述.
主要成果:
- 这名患者在首次使用合成大麻素后出现了危及生命的猫.
- 高剂量的洛拉泽帕姆被给予,但最终需要电疗法 (ECT) 来治疗.
- 这一案例代表了第一份由合成大麻素诱导的catatonia在一个天真用户的记录实例之一.
结论:
- 合成大麻素的使用可能会导致严重的精神疾病,如猫头,即使在没有以前使用大麻的个人中.
- 合成大麻素的不可预测性和不受监管的性质带来了重大的公共健康风险.
- 及时识别和积极治疗,可能包括ECT,对于管理合成大麻素诱导的猫至关重要.
相关概念视频
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
193
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
193
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
277
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
277
Drugs Acting on Autonomic Ganglia: Stimulants
1.3K
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
1.3K
CNS Stimulants: Psychedelic Agents
151
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
151
Antipsychotic Drugs: Therapeutic Uses and Side Effects
202
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
202
Parkinson's Disease: Treatment
268
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
268


