一个患有神经发育障碍的患者的利兹美胺诱导精神病
1Department of Psychiatry, Abbott Northwestern Hospital, Minneapolis, USA.
Cureus
|March 4, 2024
概括
在自闭症谱系障碍 (ASD) 中,注意力缺陷多动症 (ADHD) 的兴奋剂药物很少会导致精神病. 甲基化物可能是首选的一线兴奋剂,因为它具有更好的耐受性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发育儿科 发育儿科
背景情况:
- 自闭症谱系障碍 (ASD) 经常与注意力缺陷多动症障碍 (ADHD) 一起发生.
- 兴奋剂药物是ADHD的常见治疗方法,但罕见的副作用包括精神病.
- 有限的临床指导方针存在于伴随性ASD和ADHD的兴奋剂选择.
研究的目的:
- 报告与lisdexamfetamine治疗的ASD和ADHD患者精神病的病例.
- 在伴随性ASD和ADHD的背景下讨论兴奋剂药物管理.
- 建议在ASD中推一种潜在的第一线兴奋剂类,用于ADHD.
主要方法:
- 一个13岁的男性患有ASD,ADHD,焦虑和抑郁症的案例报告.
- 在启动和停止兴奋剂药物治疗后观察症状的出现和消失.
- 对ADHD管理的替代兴奋剂药物的试验.
主要成果:
- 患者在开始服用lisdexamfetamine后大约一周后出现精神病.
- 在停止服用利斯德美胺后,精神病症状会消失.
- 延长释放甲基胺有效地治疗了ADHD症状,没有精神病的复发.
结论:
- 与安非他命相比,甲基酸在患有自闭症的个体中可能是ADHD的更耐受的一线兴奋剂选择.
- 在患有并发性ASD和ADHD的患者中,需要仔细考虑兴奋剂的选择.
- 需要进一步的研究,以制定明确的指导方针,在这个人群中选择兴奋剂.
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