晚年抑郁症中的肠道微生物群失调和炎症功能障碍:观察性的横截面分析
Yan Chen1, Dansheng Le1, Jiaxi Xu2
1Center for Rehabilitation Medicine, Department of Psychiatry, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Neuropsychiatric disease and treatment
|March 4, 2024
概括
晚年抑郁症 (LLD) 与肠道微生物群的变化和炎症有关. 特定的肠道细菌和炎症标志物如IL6,Akkermansia和Sutterella可以预测LLD,帮助诊断.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 晚年抑郁症 (LLD) 存在诊断挑战,原因是与成人抑郁症,认知障碍和各种临床症状重叠的标准.
- 在LLD中肠道微生物群和全身炎症之间的相互作用仍然不太清楚,这阻碍了生物标志物的发展.
研究的目的:
- 在患有LLD的个体中调查肠道微生物群组成和血清炎症性细胞因子.
- 探索肠道微生物群和炎症作为LLD潜在生物标志物的联合作用.
主要方法:
- 一项涉及29名LLD患者和33名健康对照 (HCs) 的观察性,横截面研究.
- 对便微生物群和12种血清炎症因子的分析.
- 肠道微生物群,炎症标志物和神经心理评分之间的相关性分析.
- 接收器运行特征 (ROC) 曲线分析,以确定LLD的预测生物标志物.
主要成果:
- 与HC相比,LLD患者表现出系统性炎症性细胞因子和肠道微生物群失生症的升高.
- 在LLD患者中观察到Verrucomicrobia,Megamonas,Citrobacter和Akkermansia的丰度减少.
- 在LLD患者中发现了Coprococcus,Lachnobacterium,Oscillospira和Sutterella的丰富性增加.
- IL6,IFNγ,Verrucomicrobia和Akkermansia的水平与抑郁症的严重程度相关.
- IL6,Akkermansia和Sutterella被确定为LLD的预测因素,它们的组合达到0.962.6的AUC.
结论:
- 这项研究提供了关于肠道微生物群的改变和LLD系统性炎症的证据.
- 研究结果表明,肠道微生物群和炎症在LLD病变发生过程中可能发挥作用.
- 已发现的生物标志物 (IL6,Akkermansia,Sutterella) 为临床LLD诊断提供了有前途的途径.
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