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肠道微生物群 - - 棕烯酸 - - 氨酸-5轴协调素诱导的造血毒性

Lei Zhang^1,2, Ziyan Liu¹, Wei Zhang¹

¹Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, China.

|March 4, 2024

概括

暴露会通过改变肠道细菌和增加特定脂肪酸来损害血液细胞,导致炎症. 益生菌可以防止这种素诱导的造血性毒性.

科学领域:

毒理学毒理学毒理学
微生物学微生物学
血液学血液学血液学

背景情况:

暴露是与不良血液结果相关的重大职业危险.
素诱导的造血损伤背后的精确机制尚未完全理解.
了解这些机制对于制定有效的预防策略至关重要.

研究的目的:

研究肠道微生物群-长链脂肪酸 (LCFA) -炎症轴在诱导的造血损伤中的作用.
阐明与暴露相关的特定微生物和代谢变化.
评估益生菌在减轻对血液形成的有毒作用方面的潜力.

主要方法:

C57BL/6J小鼠在45天内暴露在中.
分析了血液学参数,肠道微生物群组成,血LCFA和炎症标志物 (例如IL-5).
进行了便微生物群移植,以评估肠道微生物群的因果作用.
研究了高LCFAs,特别是棕酸 (POA) 的影响.
评估了口服益生菌的保护作用.

主要成果:

的暴露导致了剂量依赖的造血损伤,包括减少血细胞和抑制造血.
观察到肠道微生物群的显著变化,其中增加了*Bacteroides acidifaciens*和减少了*Lactobacillus murinus*.
从暴露于的捐赠者那里接受微生物群的小鼠表现出血液形成障碍和升高的LCFA和IL-5.
高血LCFA,特别是POA,通过CPT2-介导的脂肪酸氧化障碍加剧了诱导的炎症和造血损伤.
口服益生菌管理保护小鼠免受素诱导的造血性毒性.

结论:

肠道微生物群 - - 棕烯酸 (POA) - - 素-5 (IL-5) 轴在诱导的造血损伤中起着至关重要的作用.
肠道微生物群的干扰和随后LCFA的改变有助于的毒性.
益生菌显示承诺作为预防措施对诱导的造血异常.

关键词:

烯是一种烯.我们的肠道微生物群.血液中毒性血液中毒性长链脂肪酸是一种长链脂肪酸.益生菌是一种益生菌.

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