在混合结缔组织疾病和全身性硬化症患者中,指甲毛细管学异常和肺高血压
A Munteanu1, N R Kundnani, A Caraba
1The 4th Internal Medicine Department, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania. knilima@umft.ro.
European review for medical and pharmacological sciences
|March 4, 2024
概括
混合连接组织疾病 (MCTD) 中的肺动脉高血压 (PAH) 与指甲毛细血管检查 (NFC) 异常有关,特别是毛细血管密度降低. 患有PAH的全身性硬化症 (SSc) 患者也表现出NFC变化,但MCTD患者表现出更明显的微血管损伤.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 血管医学 血管医学
背景情况:
- 肺动脉高血压 (PAH) 是混合结合组织疾病 (MCTD) 和全身性硬化症 (SSc) 的严重血管并发症.
- 爪毛细膜镜 (NFC) 是评估微血管干预的宝贵工具,反映了这些条件下的全身微血管损伤.
研究的目的:
- 为了研究和比较使用NFC在MCTD和SSc患者的微血管参与,有或没有PAH.
主要方法:
- 一项涉及26名MCTD和26名SSc患者的横截面研究.
- 通过心脏超声波评估自身抗体,狼抗凝剂 (LAC) 和静脉肺动脉压 (sPAP).
- 使用数字显微镜进行NFC,以评估毛细血管密度,形态和异常.
主要成果:
- 在46.15%的MCTD患者和53.84%的SSc患者中发现了PAH.
- 患有PAH的MCTD患者显示毛细血管密度显著降低,巨毛细血管,灌木毛细血管和出血增加.
- 与没有PAH的患者相比,患有PAH的SSc患者表现出毛细血管密度降低和毛细血管茂密.
结论:
- 显著的NFC异常,特别是类似于硬质皮质的模式,使MCTD患者易患PAH.
- 减少毛细血管密度是这些患者群体中PAH发展的关键因素.
- 独特的NFC发现,特别是毛细血管密度和茂密的毛细血管,区分MCTD和SSc患有PAH的患者.
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