溶解微针的配方和评估,用于皮肤输送 piperine:聚合物度的影响
Andi Nur Aisyah1,2, Andi Dian Permana1, Elly Wahyudin1
1Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
Journal of biomaterials science. Polymer edition
|March 4, 2024
概括
这项研究开发了用piperine (DMNs PIP) 溶解微针来治疗炎症. 最佳配方表现出出色的机械强度,高透性,并被发现是无毒和安全的.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 皮佩林 (PIP) 具有抗炎性质,但面临生物可用性挑战.
- 溶解微针 (DMN) 提供了一个有前途的透皮药物递送系统.
- 优化DMN配方对于有效的药物输送和治疗结果至关重要.
研究的目的:
- 为了制定和表征溶解微针皮派林 (DMNs PIP).
- 评估聚合物度对DMN特性和*ex vivo*透性的影响.
- 评估DMNs PIP在潜在的抗炎应用中的安全性和有效性.
主要方法:
- 使用不同度的 piperine 和 polyvinyl alcohol (PVA):polyvinyl pyrrolidone (PVP) 聚合物混合物,制备了 DMN PIP.
- 描述包括形态评估,机械强度测试,密度,干燥损失 (LOD) 和piperine含量分析.
- 进行了透研究,X射线衍射 (XRD),里埃变换红外光谱 (FTIR) 和血液溶解试验.
主要成果:
- 配方F1 (PIP与PVA:PVP 30:60) 呈现出最佳的机械强度 (8.35±0.11%) 和卓越的体外透率 (95.02±1.42μg/cm2).
- XRD分析证实了水晶中存在的 piperine,而FTIR 表示 piperine 和聚合物之间没有相互作用.
- 血液溶解测试显示血液溶解指数低于5%,表明无毒性.
结论:
- 开发的DMNs PIP配方在机械上是稳定的,并表现出优异的通过皮肤透能力.
- DMNs PIP配方是无毒和安全的,为局部抗炎治疗提供了可行的替代方案.
- 优化聚合物度是实现有效的微针药物递送所需特征的关键.
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