单次抗血小板治疗后安普拉特泽左心房附属体闭塞
Anders Kramer1,2, Kasper Korsholm1,2, Jens Erik Nielsen-Kudsk1,2
1Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
概括
在左心房附属物阻塞 (LAAO) 后的单一抗血小板治疗显示,与设备相关的血栓形成和中风发生率与更密集的治疗相比,严重出血的发生率较低.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 血栓形成研究研究
背景情况:
- 最佳的抗血栓治疗后的左心房附属体封闭 (LAAO) 是争论的.
- 均衡预防与设备相关的血栓形成 (DRT) 和出血风险至关重要.
研究的目的:
- 评估Amplatzer LAAO后单次抗血小板治疗 (SAPT) 的长期安全性和有效性.
- 在一个大,连续的患者队列中评估结果.
主要方法:
- 在553名接受安普拉策LAAO (ACP或 Amulet) 治疗的患者中进行了回顾性,单中心的观察性研究.
- 从当地记录和丹麦国家卫生登记处收集的数据.
- 随访包括对临床结果的成像和注册数据.
主要成果:
- 431名高出血风险患者接受了SAPT (阿司匹林或克洛皮多格雷尔).
- 在1.5%的患者中检测到DRT;1年的缺血性中风率为2.2%.
- 一年大出血率为5.9%;心血管死亡率为2.9%.
结论:
- 在AMPLAZER LAAO之后的SAPT显示,DRT和中风的发生率与更强烈的抗血栓策略相美.
- 这种方法与较低的重大出血率有关.
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