Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Catch-and-display immunoassay for digital biomarker detection.

Nanoscale horizons·2026
Same author

Nanomembrane-based microfluidic platform with embedded electrical pressure transducer for on-chip nanoparticle quantification.

Lab on a chip·2026
Same author

A human synovial tendon-on-a-chip models key features of peritendinous adhesions and offers a new approach methodology for testing anti-fibrotic drugs.

bioRxiv : the preprint server for biology·2026
Same author

Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells.

Lab on a chip·2026
Same author

Modular Integration of Impedance Sensing for Real-Time Assessment of Barrier Integrity.

bioRxiv : the preprint server for biology·2026
Same author

Type III Collagen Promotes a Pro-Fibrotic Microenvironment for In Vitro Tendon Healing Microphysiological Systems.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026

相关实验视频

Updated: Jul 1, 2025

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue
06:20

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Published on: February 16, 2024

1.0K

将静态屏障组织模型转化为动态微生理系统

Mehran Mansouri1, Aidan R Hughes1, Lauren A Audi1

  • 1Department of Biomedical Engineering, Rochester Institute of Technology.

Journal of visualized experiments : JoVE
|March 4, 2024
PubMed
概括

研究人员开发了一种可重新配置的膜平台,它结合了开井和微流体能力. 这种多功能系统在实验室中增强了组织仿真,弥合了传统方法和先进的微生理系统之间的差距.

更多相关视频

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip
09:46

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

1.7K
Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

3.4K

相关实验视频

Last Updated: Jul 1, 2025

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue
06:20

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Published on: February 16, 2024

1.0K
Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip
09:46

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

1.7K
Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

3.4K

科学领域:

  • 生物技术和生物医学工程 生物技术和生物医学工程
  • 细胞生物学和组织工程

背景情况:

  • 微生理系统 (MPS) 提供先进的组织仿真,但由于与标准生物科学实验室协议不兼容,因此面临采用障碍.
  • 现有的基于膜的开井系统缺乏流体流动,这是模拟生理条件的关键因素.
  • 需要适应性强的平台,可以整合开井和微流体方法的好处.

研究的目的:

  • 开发一种新的可重新配置的基于膜的平台,与传统的实验室协议兼容.
  • 允许在开井和微流体模式之间无切换,增强实验灵活性.
  • 克服当前MPS的局限性,并促进其在生物科学研究中的更广泛采用.

主要方法:

  • 采用磁组装方法来创建一个可重新配置的平台.
  • 该系统允许在开井和微流体配置之间进行可逆切换.
  • 与免疫染色和RNA提取等标准技术的证明兼容性.

主要成果:

  • 成功创建了一个可重新配置的膜平台,具有开放式井结构和流量增强能力.
  • 验证了系统与标准开井协议和技术的兼容性.
  • 在实验中展示了在开井和微流体模式之间过渡的能力.

结论:

  • 可重新配置的平台通过整合灵活性和兼容性来解决当前微生理系统的局限性.
  • 这种设计预计将增加工程和生物科学实验室中先进组织模拟平台的采用.
  • 该系统有助于使用既定协议,同时可以将流体流量纳入更多生理学相关的研究.