非性状态:在发展中国家的临床发现,EEG特征和预后,墨西哥
Daniel San-Juan1, Erick B Ángeles2, María Del Carmen F González-Aragón2
1Epilepsy Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico.
概括
这项研究描述了墨西哥的非性状态 (NCSE),发现年龄,昏迷和围产期缺氧会对预后产生负面影响,而缺乏普遍的EEG减缓会改善预后. 这项研究解决了发展中国家对NCSE理解的差距.
科学领域:
- 神经学 神经学
- 发病学 (Epileptology) 是一个专业的学科.
- 临床神经科学 临床神经科学
背景情况:
- 尽管墨西哥在美洲发病率最高,但发展中国家对非性状态 (NCSE) 的研究不足.
- 关于该地区NCSE的临床和流行病学数据有限.
研究的目的:
- 描述墨西哥第三级护理中心NCSE患者的临床表现,脑电图 (EEG) 发现和结果.
- 在发展中国家的背景下,确定影响NCSE预后的因素.
主要方法:
- 在2010年至2020年期间被诊断患有NCSE的134名患者 (≥15岁) 的回顾性病例系列.
- 数据收集包括人口统计,史,临床表现,触发因素,病因,EEG模式和治疗结果.
- 统计分析涉及描述性统计和多项逻辑回归.
主要成果:
- 队列 (54.8%的女性,平均年龄为39.5岁) 主要有史 (71%).
- 意识改变 (82%) 和昏迷 (27.7%) 是常见的;一般化的NCSE模式是最常见的 (32.1%).
- 异常病因 (56%) 和不受控制的 (48%) 是主要的触发因素,54.5%的患者得到缓解和改善.
结论:
- 对NCSE预后产生负面影响的因素包括年龄较大,患有围产期缺氧史,昏迷和焦点点脑电图模式.
- 没有普遍的EEG减速与明显更好的预后有关.
- 调查结果强调了在资源有限的环境中NCSE管理的关键预测指标.
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